Vioxx Research Today is a free monthly online journal that collates and summarizes the latest research about Vioxx, including details on osteoarthritis, side-effects, trials, stroke, heart attack.

Volume 5 (2008), Issue 8 (August)

1. Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology.
   Trends Pharmacol Sci, 29(8): 391-7. [Abstract] [Full-text]
2. Thermodynamic behavior of glassy state of structurally related compounds.
   Eur J Pharm Biopharm, 69(3): 1067-76. [Abstract] [Full-text]
3. Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib.
   Arthritis Rheum, 59(8): 1105-11. [Abstract] [Full-text]
4. Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups.
   Arthritis Rheum, 59(8): 1097-104. [Abstract] [Full-text]
5. Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: a nested, case-control study.
   Arthritis Rheum, 59(8): 1090-6. [Abstract] [Full-text]
6. Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.
   J Med Chem, 51(15): 4476-81. [Abstract] [Full-text]
7. Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs.
   Invest New Drugs. [Abstract] [Full-text]
8. Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases.
   J Pharmacol Exp Ther, 326(3): 745-53. [Abstract] [Full-text]
9. Using the CatWalk method to assess weight-bearing and pain behaviour in walking rats with ankle joint monoarthritis induced by carrageenan: effects of morphine and rofecoxib.
   J Neurosci Methods, 174(1): 1-9. [Abstract] [Full-text]
10. Adaptation of Bayesian data mining algorithms to longitudinal claims data: coxib safety as an example.
    Med Care, 46(9): 969-75. [Abstract] [Full-text]
11. In vivo and in vitro metabolism of lefucoxib in rats.
    J Pharm Biomed Anal, 48(1): 134-9. [Abstract] [Full-text]
12. Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban).
    Crit Care Med, 36(9): 2576-82. [Abstract] [Full-text]

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