Vioxx Research Today is a free monthly online journal that collates and summarizes the latest research about Vioxx, including details on osteoarthritis, side-effects, trials, stroke, heart attack.

Volume 2 (2005), Issue 7 (July)

1. Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids.
   Biomed Chromatogr, 19(5): 362-8. [Abstract] [Full-text]
2. Pre-column derivatization of rofecoxib for determination in serum by HPLC.
   Anal Bioanal Chem, 382(5): 1265-8. [Abstract] [Full-text]
3. Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results.
   Pain, 116(3): 322-31. [Abstract] [Full-text]
4. The trade-off between cardiovascular and gastrointestinal effects of rofecoxib.
   Pharmacoepidemiol Drug Saf, 14(7): 437-41. [Abstract] [Full-text]
5. Powering our way to the elusive side effect: a composite outcome 'basket' of predefined designated endpoints in each organ system should be included in all controlled trials.
   J Clin Epidemiol, 58(8): 785-90. [Abstract] [Full-text]
6. A novel celecoxib derivative potently induces apoptosis of human synovial fibroblasts.
   J Pharmacol Exp Ther, 314(2): 796-803. [Abstract] [Full-text]
7. Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro.
   Br J Pharmacol, 145(6): 740-50. [Abstract] [Full-text]
8. Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2.
   Prostaglandins Leukot Essent Fatty Acids, 73(2): 103-11. [Abstract] [Full-text]
9. Transfer of rofecoxib into human milk.
   Eur J Clin Pharmacol, 61(5): 405-8. [Abstract] [Full-text]
10. Monitoring the safety of licensed medicines.
    Nat Rev Drug Discov, 4(7): 541-3. [Abstract] [Full-text]
11. Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells.
    FASEB J, 19(10): 1353-5. [Abstract] [Full-text]

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