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Intracranial hypertension induced by rofecoxib.

Jacob S, Rajabally YA

University Hospitals of Leicester, Neurology, Leicester, UK.

Several secondary causes are implicated in the etiology of idiopathic intracranial hypertension. Rofecoxib is a selective cyclo-oxygenase (COX)-2 inhibitor, now being increasingly used in place of nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of intracranial hypertension in a 69-year-old man 3 weeks after the commencement of rofecoxib therapy with reversal of clinical findings on drug withdrawal.

Published 24 January 2005 in Headache, 45(1): 75-6.
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